منابع مشابه
Time to think outside the (genetic) box.
Many patients develop cancers that have clinical features of inherited syndromes (e.g., young age of onset and unique pathology) but lack mutations in the genes characteristic of the disease. In this issue of the journal, Wong et al. report that somatic epigenetic inactivation could explain some such cases in the setting of BRCA1-associated breast cancer. Here, we discuss the implications of th...
متن کاملAcute dysphagia after a normal endoscopy: think outside the box.
A 45-year old lady with Lynch Syndrome (also known as hereditary non-polyposis colorectal cancer) attended the endoscopy department for an upper and lower gastrointestinal endoscopy as part of her cancer surveillance programme. She had no previous history of intraor extra-intestinal malignancies and her past medical history was otherwise unrevealing. The endoscopic investigations were uneventfu...
متن کاملExtracellular neurotransmitter receptor clustering: think outside the box.
Postsynaptic submembrane scaffolds cluster neurotransmitter receptors through intracellular protein-protein interactions. Growing evidence supports the view that extracellular factors can be almost as important to trigger synaptic receptor aggregation.
متن کاملThe Urgent Need to Re-Think Outside the “Omega-3 Pufas” Box
Today, there is a growing controversy on the association of intake of omega-3 polyunsaturated fatty acids (PUFAs) and the onset of cardiovascular diseases (CVDs) in humans. Some studies suggest that the consumption of oily fish leads to increased levels of omega-3 PUFAs and thereafter a favourable cardiovascular prognosis. These views have been supported by epidemiological data evaluated by met...
متن کاملRecognition of hypovolemic shock: using base deficit to think outside of the ATLS box
Base deficit has frequently been utilized as an informal adjunct in the initial evaluation of trauma patients to assess the extent of their physiologic derangements. However, the current Advanced Trauma Life Support (ATLS) classification system for hypovolemic shock does not include base-deficit measurements and relies primarily on alterations in vital signs (heart rate, systolic blood pressure...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmacy Today
سال: 2016
ISSN: 1042-0991
DOI: 10.1016/j.ptdy.2016.07.028